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Effect of losartan and atenolol on insulin sensitivity in nondiabetic hypertensive patients

  • 1.  Effect of losartan and atenolol on insulin sensitivity in nondiabetic hypertensive patients

    Posted 11 days ago




    . 2016 Apr-Jun;7(2):80-6.
     doi: 10.4103/0976-500X.184771.

    Effect of losartan and atenolol on insulin sensitivity in nondiabetic hypertensive patients

    Affiliations 
      • PMID: 27440952
        Free PMC article

    Abstract

    Objective: To study the effects of losartan and atenolol on glucometabolic parameters in nondiabetic hypertensive patients.

    Materials and methods: In a prospective, open-label, parallel group study, nondiabetic patients with mild to moderate hypertension were randomized to either losartan (titrated from 50 to 100 mg/day, n = 20) or atenolol (titrated from 25 mg to 100 mg/day, n = 20) for period of 24 weeks. At baseline, 12 and 24 weeks fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment for insulin resistance (HOMA-IR) apart from lipid parameters, mean systolic, and diastolic blood pressures levels were determined.

    Results: At the end of study, losartan significantly (P < 0.05) reduced FPG, FPI, and HOMA-IR compared to atenolol and baseline. While atenolol increased the HOMA-IR levels significantly compared to the baseline.

    Conclusions: Losartan improved the insulin sensitivity while atenolol worsened it. Losartan is better than atenolol for its effects on the glucose-insulin metabolism.

    Keywords: Atenolol; hypertension; insulin resistance; losartan.

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    Charles Crow RN MA FAACVPR
    Manager Cardiac Rehabilitation Program
    Ascension
    War Eagle AU
    Charles.crow@ascension.org
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